01/05/2015 13:32:00.65  OWSTIMER.EXE (0x06CC)             0x0760  SharePoint Portal Server              User Profiles      d22b                High       Failure retrieving application ID for User Profile Application Proxy ‘User Profile Service Application Proxy’: Microsoft.Office.Server.UserProfiles.UserProfileApplicationNotAvailableException: UserProfileApplicationNotAvailableException_Logging :: UserProfileApplicationProxy.ApplicationProperties ProfilePropertyCache does not have d4b21338-a0b4-40f2-9e07-1642409d1f34     at Microsoft.Office.Server.Administration.UserProfileApplicationProxy.get_ApplicationProperties()     at Microsoft.Office.Server.Administration.UserProfileApplicationProxy.get_AppID()           1fdcdc9c-a0a0-c0c4-5a6c-67586a3db558


The MOST IMPORTANT THING about SharePoint:

Open ULSViewer.  Find an entry that has a category of User Profiles.  Right-click and Quick Filter for Category=User Profiles

This will show you everything related to the User Profile Synchronization process.

We deleted and recreated our User Profiles Application Service (we destroyed our database because user my sites had no meaningful information.)

We changed the Application Pool account from NETWORK SERVICE  to our farm account.  We validated all the permissions as stated here: http://www.harbar.net/articles/sp2010ups2.aspx

The next fix was to go to Central Administration->Manage Service Applications.  Select User Profiles Application Service.  Click Permissions in the ribbon.  Add the service account.

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